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Objective To evaluate the targeted antimicrobial prophylaxis in men undergoing trans-rectal ultrasound guided prostate biopsy based on rectal swab culture results.Methods From July 2008 to April 2012 we studied differences in infectious complications in men who received targeted vs standard empirical ciprofloxacin prophylaxis before transrectal ultrasound guided prostate biopsy.All 344 patients were divided into 3 groups according to their hospital records,inculding group A:without antimicrobial prophylaxis(105 eases) ;group B:antimicrobial prophylaxis with fluoroquinolone(117 cases) ;group C:targeted prophylaxis used rectal swab cultures results(122eases).All cases received enema with diluted iodophors before biopsy.We identified men with infectious complications within 7 days after transrectal ultrasound guided prostate biopsy using the electronic medical record,following 3 conditions.Results In group A of 105 case,17 cases of fever were recorded,including prostatic abscess of 3 cases and septicemia of 1 case.Three cases of fever were occurred in group B,including 1 case of bacteremia and 1 case of prostatitis.No infectious complications were recorded in group C.Conclusions Targeted antimicrobial prophylaxis was associated with a notable decrease in the incidence of infections complications after transrectal ultrasound guided prostate biopsy,although fiuoroquinolone can provide good protective effets.
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OBJECTIVE To study the antimicrobial sensitivity of pathogens isolated from diabetic foot patients. METHODS Totally 102 diabetic foot patients were enrolled from Jun 2000 to Dec 2007 in our hospital.Specimens such as pus and wound exudate were collected for culture.Pathogenic spectrum and antimicrobial sensitivities were investigated. RESULTS From 70 cases 109 strains of pathogenic bacteria were isolated,of which 61 were Gram-positive bacteria,43 Gram-negative bacteria and 5 fungi.Thirty-seven patients were with single microbial infection and 33 patients with polymicrobial infection and 28 of 33 patients were with Wagner′s grade 3 and upwards.According to susceptibility test,multi-drug resistance was found.Gram-negative bacteria were sensitive to imipenem and ?-lactamases inhibitor,and Gram-positive bacteria were sensitive to vancomycin,chloramphenicol,and cephalosporin. CONCLUSIONS The pathogenic bacteria in diabetic foot infection distribute extensively and some of them are multi-drug resistant.The key to the treatment of diabetic foot infection is early combination application of sensitive antimicrobial agents.
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BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen that is frequently involved in outbreaks of nosocomial infections. We did moleculoepidemiological analysis of MRSA strains isolated at the Dongsan Medical Center from January 1998 to June 1998 by means of a pulsed-field gel electrophoresis (PFGE) and antimicrobial resistance phenotyping. METHODS: One hundred six strains of MRSA, isolated from patients, were analyzed and classified by DNA fingerprinting with PFGE by CHEF-DR III (Bio-Rad Co., USA) after digestion with SmaI. An antimicrobial sensitivity test was performed and the patterns were compared to the PFGE patterns. RESULTS: Among the 106 isolates, 28 different PFGE patterns were identified. Nineteen patterns were responsible for more than one strain (2 to 24 strains). Twenty-seven patterns showed over 65% in the similarity coefficient and were classified into 8 groups (I-VIII). Group II strains were mostly isolated from wound and sputum, whereas group III from pleural fluid and urine. Most of group II isolates were from patients of the wards (40% of NS isolates, 71% of OS isolates and 60% of IM isolates) and ICUs (50% of SICU and MICU isolates). The antibiogram separated the isolates into 11 types. Type 6 was predominant and subdivided into groups II, III and VII of the PFGE patterns. CONCLUSIONS: Molecular chromosomal DNA fingerprinting with PFGE revealed the clonal relationships of some MRSA isolates at the Dongsan Medical Center. Thus, molecular epidemiological analysis with PFGE would be valuable for delineating epidemic isolates of MRSA, for identifying the nosocomial reservoirs, and for tracing their intrahospital spread.